Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036491 | 0.94 | KMT2A (0.44) | ALDH1A1HPGDHTTKDM4EKMT2A | |
| SCHEMBL5032689 | 0.92 | KMT2A (0.52) | ALDH1A1HPGDHTTKDM4EKMT2A | |
| SCHEMBL5041529 | 0.90 | KDM4E (0.42) | ALDH1A1HPGDHSD17B10KDM4EKMT2A | |
| SCHEMBL5042015 | 0.89 | MAPK1 (0.54) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL5034989 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL5132933 | 0.86 | MAPK1 (0.53) | ALDH1A1HPGDHTTKDM4EKMT2A | |
| SCHEMBL5036063 | 0.85 | KIF18A (0.49) | ALDH1A1HPGDHTTKDM4EKMT2A | |
| SCHEMBL5032644 | 0.85 | KMT2A (0.52) | ALDH1A1HPGDHTTKDM4EKMT2A | |
| SCHEMBL5032652 | 0.85 | KDM4E (0.44) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL5035035 | 0.83 | MAPK1 (0.55) | ALDH1A1HPGDHTTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |