Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041389 | 0.92 | KDM4E (0.46) | HPGDALDH1A1IDH2KDM4EMEN1 | |
| SCHEMBL5036481 | 0.91 | HPGD (0.40) | HPGDALDH1A1SMN1; SMN2IDH2THRB | |
| SCHEMBL5040836 | 0.90 | THRB (0.51) | HPGDALDH1A1SMN1; SMN2THRBKDM4E | |
| SCHEMBL5036085 | 0.90 | THRB (0.44) | HPGDALDH1A1SMN1; SMN2THRBKDM4E | |
| SCHEMBL5041368 | 0.89 | THRB (0.43) | HPGDALDH1A1SMN1; SMN2THRBKDM4E | |
| SCHEMBL5032593 | 0.88 | THRB (0.41) | HPGDALDH1A1SMN1; SMN2THRBKDM4E | |
| SCHEMBL5132977 | 0.87 | KMT2A (0.50) | HPGDALDH1A1SMN1; SMN2IDH2THRB | |
| SCHEMBL5032612 | 0.86 | IDH2 (0.40) | HPGDALDH1A1SMN1; SMN2IDH2THRB | |
| SCHEMBL5039113 | 0.86 | HPGD (0.42) | HPGDALDH1A1SMN1; SMN2IDH2KDM4E | |
| SCHEMBL5034989 | 0.86 | ALDH1A1 (0.40) | HPGDALDH1A1SMN1; SMN2IDH2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |