Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305155 | 0.82 | ALDH1A1 (0.50) | ALDH1A1POLBKMT2AMAPK1LMNA | |
| SCHEMBL3110206 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL11593452 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL11591733 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL11592822 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL4630680 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL304231 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL11591470 | 0.81 | EPHX1 (0.53) | ALDH1A1POLBKMT2AMAPK1THRB | |
| SCHEMBL4640870 | 0.80 | — | — | |
| SCHEMBL1078049 | 0.80 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799690-B1 | THIAZOLYL-DIHYDRO INDAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2008-04-16 | — | — | EP | disclosed |
| EP-1799690-A1 | THIAZOLYL-DIHYDRO INDAZOLES | Boehringer Ingelheim International GmbH (DE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006040281-A1 | THIAZOLYL-DIHYDRO INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-04-20 | — | — | WO | disclosed |