Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 known ✓ | P29474 | 2/20 | 0.70 |
| ▸ | NOS1 known ✓ | P29475 | 2/20 | 0.70 |
| ▸ | NOS2 known ✓ | P35228 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11512136 | 0.76 | NOS3 (0.53) | NOS3NOS1NOS2ALDH1A1MAPT | |
| SCHEMBL689553 | 0.68 | — | — | |
| Acetic Acid SCHEMBL9194364 | 0.59 | CYP1A2 (0.52) | ALDH1A1GAATP53HSD17B10GABRA5 | |
| Acetic Acid SCHEMBL8037754 | 0.58 | FFAR3 (0.54) | — | |
| Acetic Acid SCHEMBL3731603 | 0.57 | FFAR3 (0.64) | ALDH1A1MAPTKMT2AMEN1CYP1A2 | |
| Acetic Acid SCHEMBL584739 | 0.56 | — | — | |
| Acetic Acid SCHEMBL9098032 | 0.56 | — | — | |
| Acetic Acid SCHEMBL6049138 | 0.56 | FFAR3 (0.78) | ALDH1A1 | |
| Acetic Acid SCHEMBL11280978 | 0.56 | FFAR3 (0.78) | ALDH1A1 | |
| Acetic Acid SCHEMBL9296969 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101283441-B | Polishing slurry for CMP and polishing method | HITACHI CHEMICAL CO LTD | 2011-07-20 | — | — | CN | claimed |
| US-20170267895-A9 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2017-09-21 | — | — | US | disclosed |
| US-20150315419-A1 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2015-11-05 | — | — | US | disclosed |
| US-20140065825-A1 | POLISHING SLURRY FOR CMP AND POLISHING METHOD | HITACHI CHEMICAL CO., LTD. (JP) | 2014-03-06 | — | — | US | disclosed |
| CN-101283441-B | Polishing slurry for CMP and polishing method | HITACHI CHEMICAL CO LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101283441-A | Polishing slurry for CMP and polishing method | HITACHI CHEMICAL CO LTD (JP) | 2008-10-08 | — | — | CN | disclosed |
| EP-1936673-A1 | POLISHING SOLUTION FOR CMP AND METHOD OF POLISHING | Hitachi Chemical Co., Ltd. (JP) | 2008-06-25 | — | — | EP | disclosed |
| US-20070117394-A1 | Polishing slurry for CMP and polishing method | HITACHI CHEMICAL CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |