Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 6/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502305 | 0.90 | RIPK3 (0.36) | IDH1PRMT5WDR77HSD11B1 | |
| SCHEMBL6507892 | 0.89 | DPP4 (0.38) | IDH1PRMT5WDR77DPP4MPO | |
| SCHEMBL6511158 | 0.68 | DPP4 (0.56) | DPP4 | |
| SCHEMBL16824548 | 0.66 | MAOA (0.41) | IDH1DPP4MPO | |
| SCHEMBL28286565 | 0.66 | MAOA (0.41) | IDH1DPP4MPO | |
| SCHEMBL2591940 | 0.66 | SLC22A12 (0.43) | IDH1DPP4MPO | |
| SCHEMBL8665297 | 0.64 | HTT (0.37) | — | |
| SCHEMBL13142036 | 0.64 | DPP4 (0.46) | DPP4 | |
| SCHEMBL14039187 | 0.64 | MAOA (0.42) | IDH1DPP4MPO | |
| SCHEMBL13041692 | 0.63 | HTR2A (0.47) | IDH1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016911-A1 | 4-PYRIMIDONE DERIVATIVES AND THEIR USE AS PEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-02-24 | — | — | WO | claimed |
| EP-1911754-A1 | Dipeptidyl peptidase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2005016911-A1 | 4-PYRIMIDONE DERIVATIVES AND THEIR USE AS PEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-02-24 | — | — | WO | disclosed |