Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 9/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | CDC37 | Q16543 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339904 | 0.85 | ERBB2 (0.52) | ERBB2HSP90AB1HSP90AA1CDC37 | |
| SCHEMBL5131165 | 0.83 | HSP90AB1 (0.38) | ERBB2HSP90AB1HSP90AA1LMNA | |
| SCHEMBL3740870 | 0.81 | ERBB2 (0.43) | ERBB2HSP90AB1HSP90AA1DHFR | |
| SCHEMBL3113829 | 0.80 | SCN8A (0.38) | DHFRPDE4D | |
| SCHEMBL1669147 | 0.78 | ERBB2 (0.39) | ERBB2HSP90AB1HSP90AA1LMNA | |
| SCHEMBL16487086 | 0.76 | HSP90B1 (0.34) | ERBB2HSP90AB1HSP90AA1DHFRSCN9A | |
| SCHEMBL5044947 | 0.73 | ERBB2 (0.37) | ERBB2HSP90AB1HSP90AA1 | |
| SCHEMBL1966212 | 0.73 | ERBB2 (0.53) | ERBB2HSP90AB1HSP90AA1DHFR | |
| SCHEMBL14467034 | 0.73 | ERBB2 (0.41) | ERBB2HSP90AB1HSP90AA1DHFR | |
| SCHEMBL13079975 | 0.72 | GAA (0.41) | ERBB2HSP90AB1HSP90AA1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962863-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | Conforma Therapeutics Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075572-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | HSP90AB1, HSP90AA1, HSP90AB2P | ERBB2 1609/4885HSP90AB1 1/4885HSP90AA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.