Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16486831 | 0.86 | HSP90AA1 (0.38) | HSP90AB1HSP90AA1HSP90B1ERBB2MAP4K4 | |
| SCHEMBL5038825 | 0.83 | ERBB2 (0.41) | HSP90AB1HSP90AA1ERBB2LMNA | |
| SCHEMBL3466463 | 0.81 | LMNA (0.46) | MAP4K4LMNATSHRCLK1NSD2 | |
| SCHEMBL4339904 | 0.79 | ERBB2 (0.52) | HSP90AB1HSP90AA1ERBB2MAP4K4 | |
| SCHEMBL16487238 | 0.79 | LMNA (0.37) | HSP90AB1HSP90AA1HSP90B1ERBB2MAP4K4 | |
| SCHEMBL1669147 | 0.78 | ERBB2 (0.39) | HSP90AB1HSP90AA1ERBB2MAP4K4LMNA | |
| SCHEMBL16486997 | 0.75 | LMNA (0.43) | HSP90AB1HSP90AA1HSP90B1ERBB2MAP4K4 | |
| SCHEMBL11980452 | 0.74 | HSP90AB1 (0.38) | HSP90AB1HSP90AA1HSP90B1ERBB2LMNA | |
| SCHEMBL3745515 | 0.74 | HSP90AB1 (0.38) | HSP90AB1HSP90AA1HSP90B1ERBB2LMNA | |
| SCHEMBL11980438 | 0.74 | HSP90AA1 (0.36) | HSP90AB1HSP90AA1HSP90B1ERBB2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962863-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | Conforma Therapeutics Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075572-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885HSP90AA1 2/4885HSP90B1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.