Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190185 | 0.86 | POLB (0.46) | POLBKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL5039110 | 0.86 | CYP3A4 (0.42) | POLBKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL5036077 | 0.84 | CYP3A4 (0.42) | POLBKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL5035235 | 0.82 | CYP3A4 (0.45) | NPC1ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL5034905 | 0.82 | CYP3A4 (0.35) | POLBMAPTHPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL5041330 | 0.81 | CYP3A4 (0.44) | POLBKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL5034908 | 0.81 | CYP3A4 (0.43) | MAPTHTTSMN1; SMN2CYP3A4KMT2A | |
| SCHEMBL5034877 | 0.80 | CYP3A4 (0.44) | POLBKDM4ENPC1MAPTHTT | |
| SCHEMBL5041488 | 0.80 | CYP3A4 (0.42) | HTTSMN1; SMN2CYP3A4KMT2ACYP11B1 | |
| SCHEMBL5036060 | 0.79 | CYP3A4 (0.43) | KDM4ENPC1MAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |