Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038811 | 0.87 | KMT2A (0.39) | CYP3A4TP53MAPTHPGDPDE5A | |
| SCHEMBL5039137 | 0.82 | POLB (0.40) | CYP3A4MAPTHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL5039110 | 0.81 | CYP3A4 (0.42) | CYP3A4MAPTPDE5AKMT2ATHRB | |
| SCHEMBL5036060 | 0.77 | CYP3A4 (0.43) | CYP3A4MAPTHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL5041330 | 0.75 | CYP3A4 (0.44) | CYP3A4MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL5035268 | 0.75 | LIPE (0.47) | CYP3A4HPGDKMT2ACYP11B1CYP11B2 | |
| SCHEMBL5032567 | 0.75 | CYP3A4 (0.49) | CYP3A4MAPTKMT2ASMN1; SMN2CYP11B1 | |
| SCHEMBL5035238 | 0.75 | LIPE (0.45) | — | |
| SCHEMBL5035237 | 0.74 | POLB (0.46) | CYP3A4TP53MAPTHPGDKMT2A | |
| SCHEMBL5036077 | 0.73 | CYP3A4 (0.42) | CYP3A4MAPTKMT2ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |