Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778787 | 0.92 | CRHR1 (0.33) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5043695 | 0.92 | HTT (0.34) | LMNASMN1; SMN2POLBCRHR1MEN1 | |
| Trifluoroacetic Acid SCHEMBL5048824 | 0.89 | CRHR1 (0.40) | SMN1; SMN2POLBCRHR1MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5525916 | 0.88 | NR1H2 (0.35) | PKMRXRARXRBRXRGCRHR1 | |
| Trifluoroacetic Acid SCHEMBL5039802 | 0.85 | CACNA1B (0.34) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5044836 | 0.85 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5772870 | 0.83 | POLB (0.33) | LMNAMAPTSMN1; SMN2POLBCRHR1 | |
| Trifluoroacetic Acid SCHEMBL5048861 | 0.83 | MAPT (0.34) | MAPTSMN1; SMN2POLBCRHR1 | |
| SCHEMBL5518460 | 0.81 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5774524 | 0.80 | CRHR1 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432283-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-10-07 | — | — | US | disclosed |
| US-7268146-B2 | Ring fused pyrazole derivatives as CRF antagonists | PALO ALTO LLC (US) | 2007-09-11 | — | — | US | disclosed |