Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.79 |
| ▸ | SLC6A5 | Q9Y345 | 10/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3917817 | 0.96 | SLC6A9 (0.76) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL3922545 | 0.88 | SLC6A5 (1.00) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL3928603 | 0.88 | SLC6A9 (0.98) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL3928642 | 0.87 | SLC6A9 (0.81) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL5047145 | 0.86 | SLC6A9 (0.79) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL5039462 | 0.86 | SLC6A9 (0.79) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL3921678 | 0.86 | SLC6A9 (0.95) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL5046645 | 0.86 | SLC6A9 (0.92) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL3921817 | 0.85 | SLC6A9 (0.79) | SLC6A9SLC6A5MAPTMEN1KMT2A | |
| SCHEMBL5043046 | 0.84 | SLC6A9 (1.00) | SLC6A9SLC6A5MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427612-B2 | Benzoyl-piperazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1663232-B1 | 1-(2-AMINO-BENZOYL)-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | EP | disclosed |