Pyrophosphoric Acid

Pyrophosphoric Acid

SCHEMBL503971

NP(=O)(O)O.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.77
BLM P54132 1/20 0.77
TDP1 Q9NUW8 1/20 0.77
CA4 P22748 1/20 0.40
BTN3A1 O00481 2/20 0.32
INPPL1 O15357 2/20 0.32
INPP5A Q14642 2/20 0.32
SMPD1 P17405 1/20 0.32
INPP5B P32019 1/20 0.32
CA2 P00918 1/20 0.31
TPI1 P60174 1/20 0.31
ITPR3 Q14573 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrophosphoric Acid SCHEMBL28647299 0.92 FDPS (0.77) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL10770702 0.88 FDPS (0.83) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL8416891 0.88 FDPS (0.83) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL27805716 0.88 FDPS (0.83) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL29634664 0.88
Pyrophosphoric Acid SCHEMBL3654 0.88
Pyrophosphoric Acid SCHEMBL292348 0.88 FDPS (1.00) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL8851914 0.88 FDPS (1.00) FDPSBLMTDP1CA4BTN3A1
Triphosphate SCHEMBL5324872 0.86 FDPS (0.56) FDPSBLMTDP1CA4BTN3A1
Pyrophosphoric Acid SCHEMBL23537746 0.84 FDPS (0.91) FDPSBLMTDP1CA4BTN3A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11845054-B2 Methods and devices for nucleic acids synthesis GEN9, INC. (US) 2023-12-19 US disclosed
US-20230192750-A1 SALTS OF DIPHOSPHATE PHOSPHORAMIDATE OF NUCLEOSIDES AS ANTICANCER COMPOUNDS NuCana plc (GB) 2023-06-22 US disclosed
US-20230192750-A1 SALTS OF DIPHOSPHATE PHOSPHORAMIDATE OF NUCLEOSIDES AS ANTICANCER COMPOUNDS NuCana plc (GB) 2023-06-22 US disclosed
EP-3947408-B1 SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS NuCana plc (GB) 2023-06-07 EP disclosed
US-11560400-B2 Salts of diphosphate phosphoramidate of nucleosides as anticancer compounds NuCana plc (GB) 2023-01-24 US disclosed
US-11560400-B2 Salts of diphosphate phosphoramidate of nucleosides as anticancer compounds NuCana plc (GB) 2023-01-24 US disclosed
US-11560400-B2 Salts of diphosphate phosphoramidate of nucleosides as anticancer compounds NuCana plc (GB) 2023-01-24 US disclosed
EP-4043471-A1 SALTS OF DIPHOSPHATE PHOSPHORAMIDATE OF NUCLEOSIDES AS ANTICANCER COMPOUNDS Nucana PLC (GB) 2022-08-17 EP disclosed
EP-4043471-A1 SALTS OF DIPHOSPHATE PHOSPHORAMIDATE OF NUCLEOSIDES AS ANTICANCER COMPOUNDS Nucana PLC (GB) 2022-08-17 EP disclosed
EP-3947408-A1 SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS Nucana PLC (GB) 2022-02-09 EP disclosed
WO-2008027558-A2 ITERATIVE NUCLEIC ACID ASSEMBLY USING ACTIVATION OF VECTOR-ENCODED TRAITS CODON DEVICES, INC. (US) 2008-03-06 WO disclosed
WO-2007136833-A2 METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF CODON DEVICES, INC. (US) 2007-11-29 WO disclosed
WO-2007136840-A2 NUCLEIC ACID LIBRARY DESIGN AND ASSEMBLY CODON DEVICES, INC. (US) 2007-11-29 WO disclosed
WO-2007136834-A2 COMBINED EXTENSION AND LIGATION FOR NUCLEIC ACID ASSEMBLY CODON DEVICES, INC. (US) 2007-11-29 WO disclosed
WO-2007136736-A2 METHODS FOR NUCLEIC ACID SORTING AND SYNTHESIS CODON DEVICES, INC. (US) 2007-11-29 WO disclosed
WO-2007136835-A2 METHODS AND CELLS FOR CREATING FUNCTIONAL DIVERSITY AND USES THEREOF CODON DEVICES, INC (US) 2007-11-29 WO disclosed
WO-2007123742-A2 METHODS AND COMPOSITIONS FOR INCREASING THE FIDELITY OF MULTIPLEX NUCLEIC ACID ASSEMBLY CODON DEVICES, INC. (US) 2007-11-01 WO disclosed
WO-2007120624-A2 CONCERTED NUCLEIC ACID ASSEMBLY REACTIONS CODON DEVICES, INC. (US) 2007-10-25 WO disclosed
WO-2007117396-A1 NUCLEIC ACID ASSEMBLY OPTIMIZATION USING CLAMPED MISMATCH BINDING PROTEINS CODON DEVICES, INC. (US) 2007-10-18 WO disclosed
US-20070231805-A1 Nucleic acid assembly optimization using clamped mismatch binding proteins CODON DEVICES, INC. 2007-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192750-A1 SALTS OF DIPHOSPHATE PHOSPHORAMIDATE OF NUCLEOSIDES AS ANTICANCER COMPOUNDS NUDT1, TYMP, NTPCR FDPS 182/4885BLM 1468/4885TDP1 762/4885
US-11560400-B2 Salts of diphosphate phosphoramidate of nucleosides as anticancer compounds NUDT1, NTPCR, TYMP FDPS 176/4885BLM 1581/4885TDP1 790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.