Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319286 | 0.86 | SMN1; SMN2 (0.71) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL3485157 | 0.84 | GAA (0.69) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL259406 | 0.82 | MAPT (0.69) | LMNASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL7420552 | 0.82 | MAPT (0.55) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL3544478 | 0.81 | MAPT (0.72) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL3436164 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL29788065 | 0.79 | TDP1 (0.74) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL2039778 | 0.79 | TDP1 (0.74) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL4434853 | 0.79 | MAPT (0.60) | LMNASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL16900643 | 0.78 | HTT (0.63) | LMNASMN1; SMN2MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |