Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046260 | 0.79 | TP53 (0.38) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5048918 | 0.79 | TP53 (0.33) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31167832 | 0.78 | SMN1; SMN2 (0.44) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31229171 | 0.72 | TP53 (0.39) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31167907 | 0.71 | F2RL3 (0.36) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31167780 | 0.70 | TP53 (0.33) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5044187 | 0.68 | TP53 (0.36) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31167970 | 0.68 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30858928 | 0.66 | TP53 (0.44) | TP53NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31167876 | 0.65 | TP53 (0.40) | TP53NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744720-B1 | KERATIN DYEING COMPOSITIONS CONTAINING bicyclic 5-5 heteroaromatic compounds | PROCTER & GAMBLE (US) | 2008-11-26 | — | — | EP | claimed |
| US-7229480-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2007-06-12 | — | — | US | claimed |
| US-20050188476-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE COMPANY, THE | 2005-09-01 | — | — | US | claimed |
| EP-1744720-B1 | KERATIN DYEING COMPOSITIONS CONTAINING bicyclic 5-5 heteroaromatic compounds | PROCTER & GAMBLE (US) | 2008-11-26 | — | — | EP | disclosed |
| US-7229480-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1744720-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | The Procter and Gamble Company (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050188476-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE COMPANY, THE | 2005-09-01 | — | — | US | disclosed |
| WO-2005079735-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050188476-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | KRT18, JUP, CKMT1A; CKMT1B | TP53 921/4885NPC1 4827/4885RAB9A 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.