SCHEMBL504022

SCHEMBL504022

CCc1ccc(CCO)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.56
CYP1A2 P05177 2/20 0.54
CYP2D6 P10635 1/20 0.54
KDM4E B2RXH2 5/20 0.44
L3MBTL1 Q9Y468 3/20 0.44
PPARG P37231 3/20 0.43
CYP3A4 P08684 2/20 0.42
RXRA P19793 1/20 0.42
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
POLB P06746 2/20 0.37
CA2 P00918 1/20 0.35
MAPT P10636 3/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
TSHR P16473 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18233537 0.85 HRH3 (0.41) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL2380517 0.83 HRH3 (0.50) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL2619346 0.83 HRH3 (0.59) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL28975569 0.81 HRH3 (0.44) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL487617 0.81 HRH3 (0.55) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL30398570 0.81 HRH3 (0.55) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL2619348 0.80 HRH3 (0.56) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL11860121 0.80 HRH3 (0.56) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL3840575 0.80 HRH3 (0.56) HRH3CYP1A2CYP2D6KDM4EL3MBTL1
SCHEMBL22404255 0.80 HRH3 (0.56) HRH3CYP1A2CYP2D6KDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4314945-B1 ELECTROCHROMIC ELEMENT, ELECTROCHROMIC DISPLAY DEVICE, ELECTROCHROMIC LIGHT-CONTROLLING DEVICE, AND ELECTROLYTE COMPOSITION RICOH CO LTD (JP) 2025-12-17 EP claimed
CN-119798143-A Synthesis method of 5-ethyl-2-pyridine ethanol 安徽尖峰北卡药业有限公司 2025-04-11 CN claimed
CN-116496207-A Method for green synthesis of 4- [2- (5-ethyl-2-pyridyl) ethoxy ] benzaldehyde 上海北卡医药技术有限公司 2023-07-28 CN claimed
CN-108484488-B Method for synthesizing 4- [2- (5-ethyl-2-pyridyl) ethoxy ] benzaldehyde by photo/nickel concerted catalysis 陕西师范大学 2021-06-08 CN claimed
CN-108484488-A A kind of method of light/nickel concerted catalysis synthesis 4- [2- (5- ethyl -2- pyridyl groups) ethyoxyl] benzaldehyde 陕西师范大学 2018-09-04 CN claimed
EP-2310367-A1 A PROCESS FOR THE PREPARATION OF 4-Ý2-(5-ETHYL-2-PYRIDYL)ETHOXY¨NITROBENZENE AND PIOGLITAZONE ERREGIERRE S.p.A. (IT) 2011-04-20 EP claimed
US-20110046382-A1 PROCESS FOR THE PREPARATION OF 4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]NITROBENZENE AND PIOGLITAZONE ERREGIERRE S.P.A. (IT) 2011-02-24 US claimed
WO-2009133576-A1 A PROCESS FOR THE PREPARATION OF 4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]NITROBENZENE AND PIOGLITAZONE ERREGIERRE S.P.A. (IT) 2009-11-05 WO claimed
US-20090118514-A1 PROCESSES FOR PREPARING PIOGLITAZONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS DR. REDDY'S LABORATORIES, INC. 2009-05-07 US claimed
WO-2004108721-A1 PROCESS FOR THE PREPARATION OF 5-[[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL] METHYL]-2,4-THIAZOLIDINEDIONE SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2004-12-16 WO claimed
EP-4314945-B1 ELECTROCHROMIC ELEMENT, ELECTROCHROMIC DISPLAY DEVICE, ELECTROCHROMIC LIGHT-CONTROLLING DEVICE, AND ELECTROLYTE COMPOSITION RICOH CO LTD (JP) 2025-12-17 EP disclosed
CN-120463701-B Method for continuously preparing pioglitazone intermediate through microtubules 浙江大学 2025-09-12 CN disclosed
CN-120463701-A Method for continuously preparing pioglitazone intermediate through microtubules 浙江大学 2025-08-12 CN disclosed
CN-119798143-A Synthesis method of 5-ethyl-2-pyridine ethanol 安徽尖峰北卡药业有限公司 2025-04-11 CN disclosed
US-20240184178-A1 ELECTROCHROMIC ELEMENT, ELECTROCHROMIC DISPLAY DEVICE, ELECTROCHROMIC LIGHT-CONTROLLING DEVICE, AND ELECTROLYTE COMPOSITION RICOH COMPANY, LTD. (JP) 2024-06-06 US disclosed
US-4812570-A Method for producing thiazolidinedione derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-03-14 US disclosed
EP-0257781-A1 A method for producing thiazolidinedione derivatives Takeda Chemical Industries, Ltd. (JP) 1988-03-02 EP disclosed
US-4687777-A pioglitazone and salts TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-08-18 US disclosed
EP-0193256-A1 Thiazolidinedione derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1986-09-03 EP disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118514-A1 PROCESSES FOR PREPARING PIOGLITAZONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS DPP4, SLC5A2, SLC5A1 HRH3 2830/4885CYP1A2 671/4885CYP2D6 127/4885
US-20110046382-A1 PROCESS FOR THE PREPARATION OF 4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]NITROBENZENE AND PIOGLITAZONE HNF4A, PPARA, CYP2E1 HRH3 3227/4885CYP1A2 107/4885CYP2D6 591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.