Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420196 | 0.79 | POLB (0.53) | POLBALDH1A1 | |
| SCHEMBL5040272 | 0.76 | POLB (0.52) | POLBALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL4421502 | 0.73 | POLB (0.57) | POLBALDH1A1HTTGRM5 | |
| SCHEMBL4423553 | 0.72 | POLB (0.55) | POLBALDH1A1MAPK1HTT | |
| SCHEMBL4426528 | 0.71 | POLB (0.67) | POLBALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL4427151 | 0.71 | ALDH1A1 (0.68) | POLBALDH1A1TSHRMAPK1RAB9A | |
| Hydrochloric Acid SCHEMBL4432944 | 0.71 | POLB (0.54) | POLBALDH1A1MAPK1HTT | |
| SCHEMBL4418749 | 0.71 | ALDH1A1 (0.58) | POLBALDH1A1HTT | |
| SCHEMBL4423273 | 0.70 | POLB (0.56) | POLBALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL13669686 | 0.70 | POLB (0.53) | POLBALDH1A1HTTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | claimed |