Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.53 |
| ▸ | F7 | P08709 | 8/20 | 0.53 |
| ▸ | F10 | P00742 | 8/20 | 0.53 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PROC | P04070 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5041219 | 0.99 | PRSS1 (0.52) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5045503 | 0.92 | PRSS1 (0.53) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5045510 | 0.92 | PRSS1 (0.53) | F2PRSS1F7F10MRGPRX1 | |
| SCHEMBL5038211 | 0.86 | F2 (0.51) | F2PRSS1F7F10MRGPRX1 | |
| SCHEMBL5037610 | 0.86 | PKM (0.49) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5038201 | 0.85 | F2 (0.51) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5037603 | 0.85 | PKM (0.48) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5038024 | 0.84 | F2 (0.53) | F2PRSS1F7F10MRGPRX1 | |
| SCHEMBL5037795 | 0.84 | F2 (0.55) | F2PRSS1F7F10MRGPRX1 | |
| Hydrochloric Acid SCHEMBL5038022 | 0.84 | F2 (0.53) | F2PRSS1F7F10MRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129238-B2 | Mandelic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-10-31 | — | — | US | claimed |
| US-20040122057-A1 | Novel mandelic acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-24 | — | — | US | claimed |
| EP-1567498-B1 | MANDELIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | EP | disclosed |
| US-7129238-B2 | Mandelic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1567498-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| US-20040122057-A1 | Novel mandelic acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-24 | — | — | US | disclosed |
| WO-2004048335-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122057-A1 | Novel mandelic acid derivatives | F7, F11, F9 | F2 13/4885PRSS1 233/4885F7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.