Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041420 | 0.94 | KMT2A (0.56) | KMT2AKDM4EHTTMAPK1RXFP1 | |
| SCHEMBL5032644 | 0.92 | KMT2A (0.52) | KMT2AKDM4EHTTMAPK1EPHX2 | |
| SCHEMBL5049476 | 0.90 | MAPK1 (0.77) | KMT2AKDM4EHTTMAPK1RXFP1 | |
| SCHEMBL5039093 | 0.90 | KDM4E (0.49) | KMT2AKDM4EHTTMAPK1MEN1 | |
| SCHEMBL5036550 | 0.90 | KDM4E (0.49) | KMT2AKDM4EHTTMAPK1ALDH1A1 | |
| SCHEMBL5039201 | 0.90 | MAPK1 (0.69) | KMT2AKDM4EHTTMAPK1EPHX2 | |
| SCHEMBL5039222 | 0.87 | MAPK1 (0.68) | KMT2AKDM4EHTTMAPK1RXFP1 | |
| SCHEMBL5041386 | 0.87 | KMT2A (0.47) | KMT2AKDM4EHTTMAPK1MEN1 | |
| SCHEMBL5032671 | 0.87 | MAPK1 (0.71) | KMT2AKDM4EHTTMAPK1MEN1 | |
| SCHEMBL5032689 | 0.85 | KMT2A (0.52) | KMT2AKDM4EHTTMAPK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |