Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039222 | 0.93 | MAPK1 (0.68) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5039201 | 0.91 | MAPK1 (0.69) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5046598 | 0.89 | MAPK1 (0.88) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5035035 | 0.89 | MAPK1 (0.55) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5035270 | 0.88 | MAPK1 (0.54) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5041469 | 0.87 | KMT2A (0.63) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5036107 | 0.86 | MAPK1 (0.52) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5044864 | 0.83 | MAPK1 (0.77) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5050007 | 0.83 | MAPK1 (0.84) | MAPK1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL5039082 | 0.83 | KDM4E (0.49) | MAPK1KMT2AKDM4EHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |