Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930646 | 0.86 | PKM (0.52) | LMNATRIM24CTDSP1TP53CA12 | |
| SCHEMBL29813063 | 0.85 | LMNA (0.56) | LMNACA12CA1CA2CA9 | |
| SCHEMBL25901847 | 0.85 | CA1 (0.42) | CA12CA1CA2CA9CA7 | |
| SCHEMBL21156445 | 0.84 | LMNA (0.40) | LMNATRIM24CA12CA1CA2 | |
| SCHEMBL25902276 | 0.84 | FFAR1 (0.49) | CA12CA1CA2CA9CA7 | |
| SCHEMBL21157746 | 0.83 | CA1 (0.49) | LMNACA12CA1CA2CA9 | |
| SCHEMBL27669127 | 0.83 | CA1 (0.65) | CA12CA1CA2CA9CA7 | |
| SCHEMBL6396284 | 0.83 | LMNA (0.47) | LMNATRIM24CTDSP1TP53CA12 | |
| SCHEMBL3737092 | 0.83 | CTDSP1 (0.47) | LMNATRIM24CTDSP1TP53CA12 | |
| SCHEMBL25902045 | 0.81 | TDP1 (0.58) | TP53CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |