Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034092 | 0.77 | CHRNB2 (0.60) | CHRNB2CHRNA4 | |
| SCHEMBL5375966 | 0.70 | CHRNB2 (0.47) | CHRNB2CHRNA4 | |
| SCHEMBL16814954 | 0.66 | TPH1 (0.44) | MAP3K12LMNA | |
| SCHEMBL5379764 | 0.65 | CHRNB2 (0.50) | CHRNB2CHRNA4JAK1 | |
| SCHEMBL5367908 | 0.65 | CHRNB2 (0.50) | CHRNB2CHRNA4JAK1 | |
| SCHEMBL5375904 | 0.64 | CHRNB2 (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL5036834 | 0.64 | CHRNB2 (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL25190320 | 0.63 | MAP3K12 (0.50) | MAP3K12 | |
| SCHEMBL21262509 | 0.63 | MAP3K12 (0.47) | MAP3K12 | |
| SCHEMBL6998768 | 0.63 | CHRNB2 (0.55) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359152-B1 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | ABBOTT LAB (US) | 2008-05-07 | — | — | EP | claimed |