Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146489 | 0.96 | TSHR (0.39) | TSHRCASP1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL3138187 | 0.96 | TSHR (0.39) | TSHRCASP1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL3144028 | 0.96 | TSHR (0.39) | TSHRCASP1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL1379941 | 0.96 | — | — | |
| SCHEMBL57874 | 0.96 | — | — | |
| SCHEMBL3142403 | 0.96 | TSHR (0.39) | TSHRCASP1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL1378195 | 0.96 | — | — | |
| SCHEMBL285689 | 0.91 | — | — | |
| SCHEMBL28397186 | 0.82 | — | — | |
| SCHEMBL127435 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747198-B1 | ADAMANTYL PYRROLIDIN-2-ONE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-06-04 | — | — | EP | disclosed |