Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22743879 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL11977440 | 0.69 | NPC1 (0.41) | ALDH1A1MAPTCYP1A2KDM4ENPC1 | |
| SCHEMBL7929258 | 0.68 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL5550904 | 0.68 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL941324 | 0.68 | MAPT (0.42) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL223759 | 0.67 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL24650610 | 0.66 | CYP1A2 (0.34) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL10573026 | 0.66 | ALDH1A1 (0.54) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL4918873 | 0.66 | ALDH1A1 (0.54) | ALDH1A1MAPTHPGDGLAACHE | |
| SCHEMBL2657414 | 0.66 | NPC1 (0.46) | ALDH1A1MAPTHPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465741-B2 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-16 | — | — | US | disclosed |
| US-7465741-B2 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-16 | — | — | US | disclosed |
| US-7462717-B2 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-09 | — | — | US | disclosed |
| US-7462717-B2 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-09 | — | — | US | disclosed |
| EP-1532155-B1 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1532155-B1 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1537124-B1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1537124-B1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | EP | disclosed |
| CN-1329396-C | C-substituted tricyclic isoxazol 58743azoline derivatives and their use as antidepressants | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | CN | disclosed |
| CN-1303085-C | C6- and C9-substituted isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2007-03-07 | — | — | CN | disclosed |
| EP-1537124-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1537124-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1532155-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-25 | — | — | EP | disclosed |
| EP-1532155-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018482-A8 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2005-03-24 | — | — | WO | disclosed |
| WO-2004018482-A3 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2004-04-01 | — | — | WO | disclosed |
| WO-2004018482-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
| WO-2004018482-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
| WO-2004016621-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-26 | — | — | WO | disclosed |
| WO-2004016621-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-26 | — | — | WO | disclosed |