SCHEMBL5043487

SCHEMBL5043487

C[C@@H](NC(=O)c1ccc(C(=O)O)s1)c1ccc(-c2ccccc2F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.59
HDAC4 P56524 6/20 0.59
HDAC1 Q13547 6/20 0.59
HDAC6 Q9UBN7 6/20 0.57
PDE2A O00408 1/20 0.53
NPC1 O15118 1/20 0.47
HDAC7 Q8WUI4 3/20 0.46
HDAC2 Q92769 3/20 0.46
HDAC10 Q969S8 3/20 0.46
HDAC11 Q96DB2 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC9 Q9UKV0 3/20 0.46
HDAC5 Q9UQL6 3/20 0.46
CYP2C9 P11712 1/20 0.46
ALDH1A1 P00352 4/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
MAPT P10636 1/20 0.45
GRIA4 P48058 2/20 0.43
NPSR1 Q6W5P4 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5560681 1.00 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC6PDE2A
SCHEMBL5048097 0.87 HDAC3 (0.55) HDAC3HDAC4HDAC1HDAC6PDE2A
SCHEMBL6461106 0.83 HDAC3 (0.64) HDAC3HDAC4HDAC1HDAC6NPC1
SCHEMBL5046375 0.80 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC6PDE2A
SCHEMBL5565753 0.80 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC6PDE2A
SCHEMBL6454685 0.77 HDAC3 (0.67) HDAC3HDAC4HDAC1HDAC6HDAC7
SCHEMBL6470934 0.77 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC6HDAC7
SCHEMBL6461129 0.77 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC6HDAC7
SCHEMBL5566017 0.77 HDAC1 (0.56) HDAC3HDAC4HDAC1HDAC6PDE2A
SCHEMBL5046269 0.76 HDAC3 (0.55) HDAC3HDAC4HDAC1HDAC6PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7396944-B2 Thiophene derivatives, their manufacture and use as pharmaceutical agents HOFFMANN-LA ROCHE INC. (US) 2008-07-08 US claimed