SCHEMBL6461129

SCHEMBL6461129

CC(NC(=O)c1ccc(C(=O)O)s1)c1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.62
HDAC4 P56524 6/20 0.62
HDAC1 Q13547 6/20 0.62
HDAC6 Q9UBN7 6/20 0.61
ALDH1A1 P00352 2/20 0.54
PRSS12 P56730 1/20 0.54
HDAC7 Q8WUI4 3/20 0.50
HDAC2 Q92769 3/20 0.50
HDAC10 Q969S8 3/20 0.50
HDAC11 Q96DB2 3/20 0.50
HDAC8 Q9BY41 3/20 0.50
HDAC9 Q9UKV0 3/20 0.50
HDAC5 Q9UQL6 3/20 0.50
PTGER4 P35408 2/20 0.50
CYP2C9 P11712 1/20 0.50
PTGER2 P43116 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
THRB P10828 1/20 0.47
PRCP P42785 2/20 0.47
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6470934 1.00 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6461106 0.87 HDAC3 (0.64) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6454685 0.85 HDAC3 (0.67) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6533981 0.84 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6456071 0.84 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL5045926 0.84 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC6PRSS12
SCHEMBL6454613 0.83 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6455995 0.83 NR1H4 (0.66) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL5566017 0.80 HDAC1 (0.56) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL6455555 0.80 ACACB (0.57) HDAC3HDAC4HDAC1HDAC6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1575933-A1 ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-09-21 EP claimed
WO-2004054999-A1 ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-01 WO claimed
EP-1575933-A1 ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-09-21 EP disclosed
WO-2004054999-A1 ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-01 WO disclosed