SCHEMBL5566017

SCHEMBL5566017

CC(NC(=O)c1ccc(C(=O)O)s1)c1ccc(-c2ccc(N(C)C)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.56
HDAC3 O15379 6/20 0.56
HDAC4 P56524 6/20 0.56
KMT2A Q03164 2/20 0.55
HDAC6 Q9UBN7 7/20 0.54
PDE2A O00408 1/20 0.46
HDAC7 Q8WUI4 3/20 0.45
HDAC2 Q92769 3/20 0.45
HDAC10 Q969S8 3/20 0.45
HDAC11 Q96DB2 3/20 0.45
HDAC8 Q9BY41 3/20 0.45
HDAC9 Q9UKV0 3/20 0.45
HDAC5 Q9UQL6 3/20 0.45
CYP2C9 P11712 2/20 0.45
ALDH1A1 P00352 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
PRSS12 P56730 1/20 0.42
MME P08473 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5566892 0.88 HDAC3 (0.52) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL6461106 0.81 HDAC3 (0.64) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL6454685 0.80 HDAC3 (0.67) HDAC1HDAC3HDAC4HDAC6HDAC7
SCHEMBL6470934 0.80 HDAC3 (0.62) HDAC1HDAC3HDAC4HDAC6HDAC7
SCHEMBL6461129 0.80 HDAC3 (0.62) HDAC1HDAC3HDAC4HDAC6HDAC7
SCHEMBL6533981 0.79 HDAC3 (0.61) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL6456071 0.79 HDAC3 (0.61) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL5046375 0.78 HDAC3 (0.54) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL5565753 0.78 HDAC3 (0.54) HDAC1HDAC3HDAC4KMT2AHDAC6
SCHEMBL6455995 0.77 NR1H4 (0.66) HDAC1HDAC3HDAC4HDAC6PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1778683-A1 THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-02 EP claimed
WO-2005121134-A1 THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1778683-A1 THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-02 EP disclosed
WO-2005121134-A1 THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO disclosed