Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176625 | 1.00 | CDK2 (0.48) | CDK2GSK3ACHEK1USP30JAK2 | |
| Formic Acid SCHEMBL5556316 | 0.96 | CDK2 (0.46) | CDK2GSK3ACHEK1USP30JAK2 | |
| SCHEMBL1176497 | 0.93 | CDK2 (0.42) | CDK2GSK3ACHEK1GSK3BNR4A2 | |
| SCHEMBL5047046 | 0.93 | CDK2 (0.42) | CDK2GSK3ACHEK1GSK3BNR4A2 | |
| Formic Acid SCHEMBL5561803 | 0.89 | CDK2 (0.40) | CDK2GSK3ACHEK1GSK3BGABRA1 | |
| SCHEMBL1176500 | 0.85 | JAK2 (0.37) | USP30JAK2JAK1TYK2JAK3 | |
| SCHEMBL5043676 | 0.85 | JAK2 (0.37) | USP30JAK2JAK1TYK2JAK3 | |
| SCHEMBL5044455 | 0.84 | BRD4 (0.39) | USP30JAK2JAK1TYK2JAK3 | |
| SCHEMBL1176212 | 0.84 | BRD4 (0.39) | USP30JAK2JAK1TYK2JAK3 | |
| SCHEMBL1176818 | 0.84 | GSK3B (0.48) | GSK3ACHEK1USP30JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |