Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043612 | 0.85 | PPARD (0.47) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL5047117 | 0.83 | SREBF2 (0.43) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL5044005 | 0.80 | LMNA (0.46) | SMN1; SMN2ALDH1A1LMNAHTTECE1 | |
| SCHEMBL6534119 | 0.79 | TDP1 (0.46) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL5046935 | 0.78 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL6883083 | 0.77 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPTECE1KDM4E | |
| SCHEMBL6881143 | 0.76 | KDM4E (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL5043835 | 0.76 | PPARD (0.47) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL6879680 | 0.75 | KDM4E (0.51) | SMN1; SMN2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL5047164 | 0.75 | POLB (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| CN-100360527-C | CB 1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | CN | disclosed |
| US-7135488-B2 | Pyrrolyl-thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| CN-1735611-A | CB 1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | SMN1; SMN2 3330/4885ALDH1A1 959/4885LMNA 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.