Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.41 |
| ▸ | PPARA | Q07869 | 13/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039920 | 0.92 | SPHK1 (0.43) | PPARGPPARASPHK1SPHK2STAT3 | |
| SCHEMBL1856085 | 0.89 | SPHK1 (0.42) | PPARGPPARASPHK1SPHK2STAT3 | |
| SCHEMBL4669838 | 0.89 | PPARG (0.43) | PPARGPPARASPHK1SPHK2ALDH1A1 | |
| SCHEMBL5043684 | 0.86 | PPARG (0.45) | PPARGPPARASPHK1SPHK2ALDH1A1 | |
| SCHEMBL1854141 | 0.85 | SPHK1 (0.40) | PPARGPPARASPHK1SPHK2STAT3 | |
| SCHEMBL1854919 | 0.82 | SPHK1 (0.42) | PPARGPPARASPHK1SPHK2ALDH1A1 | |
| SCHEMBL5044449 | 0.82 | ALDH1A1 (0.41) | PPARGPPARASPHK1SPHK2ALDH1A1 | |
| SCHEMBL6823058 | 0.80 | ALDH1A1 (0.40) | PPARGPPARASPHK1SPHK2ALDH1A1 | |
| SCHEMBL1855174 | 0.80 | SPHK1 (0.43) | SPHK1SPHK2STAT3ALDH1A1CHRM2 | |
| SCHEMBL1854904 | 0.80 | SPHK1 (0.43) | SPHK1SPHK2STAT3ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |