SCHEMBL5044449

SCHEMBL5044449

CCCCCCCCCCCc1noc(-c2cccc(C[NH+]([O-])Cc3ccc(S(=O)(=O)C(F)(F)F)cc3)c2)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
SPHK1 Q9NYA1 3/20 0.40
SPHK2 Q9NRA0 2/20 0.40
CHRM2 P08172 3/20 0.39
CHRM4 P08173 3/20 0.39
CHRM5 P08912 3/20 0.39
CHRM1 P11229 3/20 0.39
CHRM3 P20309 3/20 0.39
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
PPARG P37231 2/20 0.34
PPARD Q03181 2/20 0.34
PPARA Q07869 2/20 0.34
KCNH2 Q12809 6/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5043973 0.91 SPHK1 (0.45) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL4972282 0.87 SPHK1 (0.42) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL1854919 0.87 SPHK1 (0.42) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL6823058 0.84 ALDH1A1 (0.40) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL5039871 0.84 SPHK1 (0.42) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL5046496 0.82 SPHK1 (0.41) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL5039861 0.82 SPHK1 (0.42) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL1856085 0.82 SPHK1 (0.42) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL5043840 0.82 PPARG (0.41) ALDH1A1SPHK1SPHK2CHRM2CHRM4
SCHEMBL5044443 0.80 ALDH1A1 (0.39) ALDH1A1SPHK1SPHK2CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732534-B1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS SERONO LAB (CH) 2008-07-23 EP claimed
EP-1732534-A1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS Applied Research Systems ARS Holding N.V. (AN) 2006-12-20 EP claimed
WO-2005082347-A1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2005-09-09 WO claimed