Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855040 | 0.81 | SCN8A (0.40) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL7686536 | 0.75 | KCNH2 (0.43) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL7686532 | 0.75 | KCNH2 (0.43) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL7686533 | 0.75 | KCNH2 (0.43) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL1853105 | 0.74 | PTGES (0.52) | FFAR1FFAR4PTGESMMP2MMP12 | |
| SCHEMBL5676711 | 0.74 | KCNH2 (0.43) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL5678410 | 0.74 | KCNH2 (0.43) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL3936713 | 0.74 | GRM5 (0.45) | KCNH2FFAR1PTGES | |
| SCHEMBL10754443 | 0.73 | KCNH2 (0.49) | KCNH2FFAR1FFAR4CYP2D6HRH3 | |
| SCHEMBL10751583 | 0.73 | KCNH2 (0.49) | KCNH2FFAR1FFAR4CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |