Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176212 | 1.00 | BRD4 (0.39) | BRD4JAK2JAK1TYK2JAK3 | |
| Formic Acid SCHEMBL5561750 | 0.96 | BRD4 (0.37) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL5563184 | 0.93 | DYRK1A (0.40) | BRD4MTORCHRNA7KCNH2LRRK2 | |
| SCHEMBL2105493 | 0.89 | BRD4 (0.39) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL5044511 | 0.84 | CDK2 (0.48) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL1176625 | 0.84 | CDK2 (0.48) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL1176818 | 0.83 | GSK3B (0.48) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL5048250 | 0.83 | GSK3B (0.48) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL1176658 | 0.81 | CHEK1 (0.40) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL1176364 | 0.81 | CHEK1 (0.40) | JAK2JAK1TYK2JAK3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |