Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.61 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003222 | 0.95 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1TRAP1HSP90B1PDK1 | |
| SCHEMBL14925039 | 0.86 | HSP90AA1 (0.45) | HSP90AB1HSP90AA1 | |
| SCHEMBL5002735 | 0.81 | HSP90AA1 (0.47) | HSP90AB1HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL14930052 | 0.79 | HSP90AA1 (0.46) | HSP90AB1HSP90AA1 | |
| SCHEMBL5025913 | 0.78 | HSP90AA1 (0.45) | HSP90AB1HSP90AA1TRAP1HSP90B1PDK1 | |
| SCHEMBL5002732 | 0.78 | HSP90AA1 (0.68) | HSP90AB1HSP90AA1TRAP1HSP90B1PDK1 | |
| SCHEMBL5006567 | 0.78 | HSP90AB1 (0.56) | HSP90AB1HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL13707077 | 0.76 | HSP90AB1 (0.80) | HSP90AB1HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL12047171 | 0.76 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL16915557 | 0.75 | HSP90AB1 (0.60) | HSP90AB1HSP90AA1TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357573-B2 | Block copolymer conjugate of physiologically active substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2016-09-29 | — | — | US | disclosed |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2016-09-29 | — | — | US | disclosed |
| WO-2016136641-A1 | BLOCK COPOLYMER CONJUGATE OF PHYSIOLOGICALLY ACTIVE SUBSTANCE | 日本化薬株式会社 | 2016-09-01 | — | — | WO | disclosed |
| US-20150011715-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2015-01-08 | — | — | US | disclosed |
| US-20150011715-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2015-01-08 | — | — | US | disclosed |
| US-20130116253-A1 | Novel HSP90 Inhibitor | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2013-05-09 | — | — | US | disclosed |
| US-20130116431-A1 | Novel HSP90 Inhibitor | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2013-05-09 | — | — | US | disclosed |
| US-8399464-B2 | using a triazole compound; anticancer agent | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399464-B2 | using a triazole compound; anticancer agent | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399464-B2 | using a triazole compound; anticancer agent | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20090239782-A1 | High-molecular weight conjugate of resorcinol derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-09-24 | — | — | US | disclosed |
| US-20090239782-A1 | High-molecular weight conjugate of resorcinol derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-2070971-A1 | COMPOUND OF RESORCINOL DERIVATIVE WITH POLYMER | Nippon Kayaku Kabushiki Kaisha (JP) | 2009-06-17 | — | — | EP | disclosed |
| US-20080269218-A1 | Novel Hsp90 Inhibitor | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080269218-A1 | Novel Hsp90 Inhibitor | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080269218-A1 | Novel Hsp90 Inhibitor | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1857446-A1 | NOVEL HSP90 INHIBITOR | Nippon Kayaku Kabushiki Kaisha (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116253-A1 | Novel HSP90 Inhibitor | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AB1 1/4885HSP90AA1 4/4885TRAP1 19/4885 |
| US-20090239782-A1 | High-molecular weight conjugate of resorcinol derivatives | WDR48, SLC43A1, LRAT | HSP90AB1 765/4885HSP90AA1 389/4885TRAP1 1234/4885 |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | WDR48, SLC43A1, LRAT | HSP90AB1 765/4885HSP90AA1 389/4885TRAP1 1234/4885 |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | TACR1, PLAUR, LNPEP | HSP90AB1 1364/4885HSP90AA1 1435/4885TRAP1 2467/4885 |
| US-20080269218-A1 | Novel Hsp90 Inhibitor | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AB1 1/4885HSP90AA1 4/4885TRAP1 19/4885 |
| US-10357573-B2 | Block copolymer conjugate of physiologically active substance | TACR1, PLAUR, LNPEP | HSP90AB1 1364/4885HSP90AA1 1435/4885TRAP1 2467/4885 |
| US-20130116431-A1 | Novel HSP90 Inhibitor | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AB1 1/4885HSP90AA1 4/4885TRAP1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.