Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967593 | 0.89 | SPHK1 (0.41) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL6023066 | 0.82 | ALDH1A1 (0.41) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL5044258 | 0.81 | SPHK1 (0.43) | SPHK1S1PR1S1PR5KCNH2CHRM2 | |
| SCHEMBL5044385 | 0.81 | SPHK1 (0.43) | SPHK1S1PR1S1PR5KCNH2CHRM2 | |
| SCHEMBL1851791 | 0.80 | SPHK1 (0.45) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL1853209 | 0.80 | SPHK1 (0.45) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL6715546 | 0.79 | PPARG (0.48) | SPHK1PPARGPPARASRCPPARD | |
| SCHEMBL4313098 | 0.79 | SPHK1 (0.41) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL1857847 | 0.79 | SPHK1 (0.41) | SPHK1S1PR1S1PR5CHRM2CHRM4 | |
| SCHEMBL5039515 | 0.76 | SPHK1 (0.42) | SPHK1S1PR1S1PR5CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |