Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046598 | 0.94 | MAPK1 (0.88) | MAPK1KDM4EKMT2AHTTKIF18A | |
| SCHEMBL5048461 | 0.93 | MAPK1 (0.74) | MAPK1KDM4EKMT2AHTTKIF18A | |
| SCHEMBL5045216 | 0.93 | MAPK1 (0.74) | MAPK1KDM4EKMT2AHTTKIF18A | |
| SCHEMBL5045362 | 0.88 | MAPK1 (0.60) | MAPK1KDM4EKMT2AHTTKIF18A | |
| SCHEMBL5041958 | 0.88 | MAPK1 (0.65) | MAPK1KDM4EKMT2AHTTTP53 | |
| SCHEMBL5050007 | 0.87 | MAPK1 (0.84) | MAPK1KDM4EKMT2AHTTTP53 | |
| SCHEMBL5045357 | 0.86 | MAPK1 (0.71) | MAPK1KDM4EKMT2AHTTTP53 | |
| SCHEMBL5046189 | 0.86 | MAPK1 (0.68) | MAPK1KDM4EKMT2AHTTTP53 | |
| SCHEMBL5041223 | 0.85 | MAPK1 (0.62) | MAPK1KDM4EKMT2AHTTTP53 | |
| SCHEMBL5047758 | 0.85 | MAPK1 (0.85) | MAPK1KDM4EKMT2AHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378417-B2 | Pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | P2RX3, P2RX1, P2RX5 | MAPK1 1732/4885KDM4E 3638/4885KMT2A 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.