Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | GLI2 | P10070 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6022081 | 1.00 | MEN1 (0.43) | MEN1KMT2ARXFP1GLI1GLI2 | |
| SCHEMBL5045311 | 0.96 | GLI1 (0.44) | MEN1KMT2AGLI1GLI2NPC1 | |
| SCHEMBL6023305 | 0.94 | MEN1 (0.43) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL5048692 | 0.94 | MEN1 (0.43) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL5043892 | 0.91 | GLI1 (0.43) | MEN1KMT2ARXFP1GLI1GLI2 | |
| SCHEMBL6022090 | 0.91 | GLI1 (0.43) | MEN1KMT2ARXFP1GLI1GLI2 | |
| SCHEMBL5048719 | 0.90 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AHDAC2 | |
| SCHEMBL5044001 | 0.84 | MEN1 (0.42) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL1855303 | 0.78 | PTGES (0.46) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL1857111 | 0.77 | MEN1 (0.45) | MEN1KMT2ARXFP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |