Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 3/20 | 0.45 |
| ▸ | CPT2 | P23786 | 2/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 7/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | CDC25C | P30307 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882755 | 0.90 | CPT2 (0.47) | CPT1ACPT2CPT1BNOTUMMTOR | |
| SCHEMBL6879620 | 0.89 | NOTUM (0.44) | NOTUMEIF4EIDH1CDC25ACDC25B | |
| SCHEMBL6871896 | 0.88 | NOTUM (0.43) | NOTUMMTORPIK3CAEIF4EIDH1 | |
| SCHEMBL6879641 | 0.87 | IDH1 (0.46) | NOTUMEIF4EIDH1HTR2AHTR2C | |
| SCHEMBL6878789 | 0.87 | NOTUM (0.42) | NOTUMMTORPIK3CAIDH1HTR2A | |
| SCHEMBL6872874 | 0.87 | NOTUM (0.42) | CPT1ANOTUMEIF4E | |
| SCHEMBL5039354 | 0.87 | CDC25A (0.49) | CPT1ACPT2CPT1BPIK3CAEIF4E | |
| SCHEMBL5039301 | 0.86 | CDC25A (0.49) | NOTUMEIF4EPLA2G2ACDC25ACDC25B | |
| SCHEMBL6881405 | 0.86 | NOTUM (0.41) | NOTUMMTORPIK3CAEIF4EIDH1 | |
| SCHEMBL6472514 | 0.85 | CNR1 (0.45) | NOTUMEIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| CN-100360527-C | CB 1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | CN | disclosed |
| US-7135488-B2 | Pyrrolyl-thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| CN-1735611-A | CB 1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | CPT1A 717/4885CPT2 739/4885CPT1B 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.