Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 6/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879620 | 0.93 | NOTUM (0.44) | IDH1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6871896 | 0.92 | NOTUM (0.43) | IDH1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6878789 | 0.91 | NOTUM (0.42) | IDH1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6872874 | 0.91 | NOTUM (0.42) | EIF4ENOTUMMAPTLMNA | |
| SCHEMBL6879796 | 0.89 | EIF4E (0.45) | IDH1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6881405 | 0.89 | NOTUM (0.41) | IDH1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5039301 | 0.89 | CDC25A (0.49) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6472514 | 0.88 | CNR1 (0.45) | KDM4EMEN1KMT2AEIF4ENOTUM | |
| SCHEMBL6877595 | 0.88 | AR (0.47) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5045109 | 0.87 | CPT1A (0.45) | IDH1EIF4ENOTUMHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | IDH1 3182/4885KDM4E 2916/4885NPC1 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.