Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PTPRF | P10586 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 5/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871896 | 0.93 | NOTUM (0.43) | NOTUMPTPRFPTPN2PTPN1ALDH1A1 | |
| SCHEMBL6872874 | 0.93 | NOTUM (0.42) | NOTUMEIF4E | |
| SCHEMBL6878789 | 0.93 | NOTUM (0.42) | NOTUMPTPRFPTPN2PTPN1KLKB1 | |
| SCHEMBL6879641 | 0.93 | IDH1 (0.46) | NOTUMALDH1A1EIF4EKLKB1KLK1 | |
| SCHEMBL6881405 | 0.91 | NOTUM (0.41) | NOTUMPTPRFPTPN2PTPN1ALDH1A1 | |
| SCHEMBL5039301 | 0.91 | CDC25A (0.49) | NOTUMALDH1A1EIF4EKLKB1CDC25A | |
| SCHEMBL6472514 | 0.90 | CNR1 (0.45) | NOTUMALDH1A1EIF4EKDM4ETP53 | |
| SCHEMBL6884351 | 0.90 | MDM2 (0.46) | NOTUMEIF4EKLKB1KLK1CDC25A | |
| SCHEMBL6877595 | 0.89 | AR (0.47) | NOTUMPTPRFPTPN2PTPN1EIF4E | |
| SCHEMBL5045109 | 0.89 | CPT1A (0.45) | NOTUMEIF4ECDC25ACDC25BCDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | NOTUM 1360/4885PTPRF 810/4885PTPN2 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.