Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ATP4A | P20648 | 2/20 | 0.36 |
| ▸ | ATP4B | P51164 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040717 | 1.00 | CYP2C9 (0.52) | CYP2C9CYP3A4ATP4AATP4BBRD4 | |
| SCHEMBL5634862 | 0.85 | CYP3A4 (0.41) | CYP2C9CYP3A4ALDH1A1KMT2AHPGD | |
| SCHEMBL5840196 | 0.85 | CYP3A4 (0.41) | CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5634281 | 0.85 | CYP3A4 (0.41) | CYP2C9CYP3A4ATP4AATP4BBRD4 | |
| SCHEMBL6047154 | 0.79 | CDK4 (0.41) | CYP2C9CYP3A4BRD4CDK4CCND1 | |
| SCHEMBL5747928 | 0.77 | CYP3A4 (0.43) | CYP2C9CYP3A4ATP4AATP4BPDE5A | |
| SCHEMBL1814134 | 0.77 | CYP3A4 (0.43) | CYP2C9CYP3A4ATP4AATP4BPDE5A | |
| SCHEMBL1217601 | 0.77 | CYP3A4 (0.43) | CYP2C9CYP3A4ATP4AATP4BPDE5A | |
| SCHEMBL1218640 | 0.77 | CYP3A4 (0.43) | CYP2C9CYP3A4ATP4AATP4BPDE5A | |
| SCHEMBL1814676 | 0.75 | CYP3A4 (0.46) | CYP2C9CYP3A4ATP4AATP4BNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314935-B2 | Tricyclic n-acyl compounds | ALTANA PHARMA AG (DE) | 2008-01-01 | — | — | US | disclosed |
| EP-1414821-B1 | TRICYCLIC EPOXIDES | ALTANA PHARMA AG (DE) | 2006-08-16 | — | — | EP | disclosed |
| US-6927292-B2 | Tricyclic epoxides | ALTANA PHARMA AG (DE) | 2005-08-09 | — | — | US | disclosed |
| US-20050148618-A1 | Tricyclic n-acyl compounds | ALTANA PHARMA AG (DE) | 2005-07-07 | — | — | US | disclosed |
| EP-1476445-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA Pharma AG (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-20040176597-A1 | Tricyclic epoxides | ALTANA PHARMA AG (DE) | 2004-09-09 | — | — | US | disclosed |
| EP-1414821-A1 | TRICYCLIC EPOXIDES | ALTANA Pharma AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003068774-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA PHARMA AG (DE) | 2003-08-21 | — | — | WO | disclosed |
| WO-2003014119-A1 | TRICYCLIC EPOXIDES | ALTANA PHARMA AG (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148618-A1 | Tricyclic n-acyl compounds | NAT1, AADAC, CYP1B1 | CYP2C9 6/4885CYP3A4 17/4885ATP4A 2068/4885 |
| US-20040176597-A1 | Tricyclic epoxides | VKORC1, CYP2E1, CYP1A2 | CYP2C9 11/4885CYP3A4 14/4885ATP4A 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.