SCHEMBL1217601

SCHEMBL1217601

Cc1nc2c3c(ccn2c1C)C(=O)[C@H](O)[C@@H](c1ccccc1)N3

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.43
CYP2C9 P11712 5/20 0.43
ATP4A P20648 2/20 0.35
ATP4B P51164 2/20 0.35
PDE5A O76074 1/20 0.32
PDE1A P54750 1/20 0.32
PDE1B Q01064 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE1C Q14123 1/20 0.32
PDE3A Q14432 1/20 0.32
GBA1 P04062 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1218640 1.00 CYP3A4 (0.43) CYP3A4CYP2C9ATP4AATP4BPDE5A
SCHEMBL5747928 1.00 CYP3A4 (0.43) CYP3A4CYP2C9ATP4AATP4BPDE5A
SCHEMBL1814134 1.00 CYP3A4 (0.43) CYP3A4CYP2C9ATP4AATP4BPDE5A
SCHEMBL5634257 0.87 CYP3A4 (0.35) CYP3A4CYP2C9
SCHEMBL1812969 0.87 CYP3A4 (0.35) CYP3A4CYP2C9
SCHEMBL4880229 0.86 CYP3A4 (0.37) CYP3A4CYP2C9ATP4AATP4BGBA1
SCHEMBL5838692 0.85 CYP3A4 (0.33) CYP3A4CYP2C9
SCHEMBL5839023 0.85 CYP3A4 (0.35) CYP3A4CYP2C9
SCHEMBL5838814 0.84 CYP3A4 (0.34) CYP3A4CYP2C9
SCHEMBL5745833 0.81 CYP3A4 (0.36) CYP3A4CYP2C9ATP4AATP4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220370425-A1 TETRAHYDROPYRIDOETHERS FOR TREATMENT OF AMD KATAIRO GMBH (DE) 2022-11-24 US disclosed
EP-3695838-A1 TETRAHYDROPYRIDOETHERS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) Katairo GmbH (DE) 2020-08-19 EP disclosed
US-20160279111-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF AMD TAKEDA GMBH (DE) 2016-09-29 US disclosed
US-20160235724-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF STARGARDT'S DISEASE KATAIRO GMBH (DE) 2016-08-18 US disclosed
EP-3054949-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF STARGARDT'S DISEASE Katairo GmbH (DE) 2016-08-17 EP disclosed
US-9314453-B2 Tetrahydropyridoethers for treatment of AMD KATAIRO GMBH (DE) 2016-04-19 US disclosed
WO-2015052256-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF STARGARDT'S DISEASE KATAIRO GMBH (DE) 2015-04-16 WO disclosed
EP-2742939-A1 Tetrahydropyridoethers for treatment of age-related macular degeneration (AMD) Katairo GmbH (DE) 2014-06-18 EP disclosed
EP-2249829-B1 Tetrahydropyridoethers for treatment of age-related macular degeneration (AMD) KATAIRO GMBH (DE) 2014-03-12 EP disclosed
US-20130131101-A1 TETRAHYDROPYRIDOETHERS FOR TREATMENT OF AMD KATAIRO GMBH (DE) 2013-05-23 US disclosed
WO-2003016310-A1 ALKYL-SUBSTITUTED IMIDAZOPYRIDINES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS ALTANA PHARMA AG (DE) 2003-02-27 WO disclosed
WO-2003014120-A1 AMINO-SUBSTITUTED IMIDAZOPYRIDINES FOR THE TREATMENT OF GASTROINTESTINAL DISEASES ALTANA PHARMA AG (DE) 2003-02-20 WO disclosed
WO-2003014119-A1 TRICYCLIC EPOXIDES ALTANA PHARMA AG (DE) 2003-02-20 WO disclosed
EP-1115725-B1 TETRAHYDROPYRIDOETHERS ALTANA PHARMA AG (DE) 2003-01-29 EP disclosed
US-6436953-B1 ANTISECRETORY AGENTS, GASTROINTESTINAL INFLAMMATORY DISEASES; (7R,8R,9R)-2,3-DIMETHYL-8-HYDROXY-7-METHOXY-9-PHENYL-7,8,9,10-TETRAHYDRO -IMIDAZO(1,2-H)-(1,7)NAPHTHYRIDINE BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2002-08-20 US disclosed
EP-1115725-A1 TETRAHYDROPYRIDOETHERS Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-07-18 EP disclosed
US-6197783-B1 THERAPY FOR GASTROINTESTINAL DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2001-03-06 US disclosed
WO-2000017200-A1 TETRAHYDROPYRIDOETHERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-03-30 WO disclosed
EP-0971922-A1 TETRAHYDROPYRIDO COMPOUNDS Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2000-01-19 EP disclosed
WO-1998042707-A1 TETRAHYDROPYRIDO COMPOUNDS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1998-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370425-A1 TETRAHYDROPYRIDOETHERS FOR TREATMENT OF AMD ALDH1A2, TTPA, ADH7 CYP3A4 1560/4885CYP2C9 3179/4885ATP4A 2734/4885
US-20130131101-A1 TETRAHYDROPYRIDOETHERS FOR TREATMENT OF AMD PTGDR, TBXA2R, NR2E3 CYP3A4 560/4885CYP2C9 2577/4885ATP4A 2975/4885
US-20160235724-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF STARGARDT'S DISEASE STARD3, MPST, TPMT CYP3A4 1177/4885CYP2C9 3719/4885ATP4A 525/4885
US-20160279111-A1 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF AMD NR2E3, PTGDR, TBXA2R CYP3A4 556/4885CYP2C9 2357/4885ATP4A 2952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.