SCHEMBL5045298

SCHEMBL5045298

CCCC1CN([C@@H](CC)C(=O)NI)C(=O)C1C(=O)OC

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.32
HIF1A Q16665 1/20 0.32
DNTT P04053 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5048110 0.88 KAT2A (0.30)
SCHEMBL8236566 0.86 LMNA (0.40) CYP1A2HIF1ADNTT
SCHEMBL4528160 0.86 LMNA (0.40) CYP1A2HIF1ADNTT
SCHEMBL4528165 0.86 LMNA (0.40) CYP1A2HIF1ADNTT
SCHEMBL5049184 0.75 ACE (0.32) CYP1A2HIF1A
SCHEMBL25267433 0.73 ACE (0.36) CYP1A2
SCHEMBL25220839 0.73 ACE (0.36) CYP1A2
SCHEMBL433366 0.72 LMNA (0.42)
SCHEMBL433367 0.72 LMNA (0.42)
SCHEMBL8236666 0.72 LMNA (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1993998-A1 3-CARBOXY- 2-OXO-1 -PYRROLIDINE DERIVATIVES AND THEIR USES UCB Pharma, S.A. (BE) 2008-11-26 EP claimed
WO-2007065634-A1 3-CARBOXY- 2-OXO-1 -PYRROLIDINE DERIVATIVES AND THEIR USES UCB PHARMA, S.A. (BE) 2007-06-14 WO claimed
EP-1993998-A1 3-CARBOXY- 2-OXO-1 -PYRROLIDINE DERIVATIVES AND THEIR USES UCB Pharma, S.A. (BE) 2008-11-26 EP disclosed
WO-2007065634-A1 3-CARBOXY- 2-OXO-1 -PYRROLIDINE DERIVATIVES AND THEIR USES UCB PHARMA, S.A. (BE) 2007-06-14 WO disclosed