Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1858819 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1855102 | 0.80 | SPHK1 (0.42) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL6802901 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL6806996 | 0.80 | SPHK1 (0.42) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1855284 | 0.76 | SPHK1 (0.43) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1857192 | 0.74 | CHRM2 (0.40) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1856239 | 0.74 | NPC1 (0.46) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1854192 | 0.74 | MEN1 (0.47) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL5045233 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4ENPC1MAPTPKM | |
| SCHEMBL1854885 | 0.74 | MEN1 (0.47) | ALDH1A1KDM4ENPC1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |