Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050640 | 0.82 | MAPT (0.43) | IGF1RMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL6032145 | 0.73 | MAPT (0.51) | IGF1RMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL5048319 | 0.69 | IGF1R (0.49) | IGF1RMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL27918172 | 0.68 | MAPT (0.59) | MAPTSMN1; SMN2LMNAL3MBTL1ALOX12 | |
| SCHEMBL14015983 | 0.68 | ADRB1 (0.48) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL2114232 | 0.67 | ADRB1 (0.49) | MAPTHTTCCR1MAPK1 | |
| SCHEMBL11955710 | 0.66 | MAPT (0.59) | IGF1RMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL3972047 | 0.65 | MAPT (0.54) | IGF1RMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL2115330 | 0.65 | ADRB1 (0.69) | — | |
| SCHEMBL6704538 | 0.64 | IDO1 (0.46) | HTR1AHTR7SLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973880-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087585-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |