Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048436 | 0.77 | MAPT (0.46) | IGF1RMAPTSMN1; SMN2LMNAALOX12 | |
| SCHEMBL5048385 | 0.74 | CCR1 (0.41) | MAPTSMN1; SMN2LMNAMAPK1HTR1A | |
| Hydrochloric Acid SCHEMBL5051976 | 0.73 | CCR1 (0.41) | MAPTSMN1; SMN2LMNAMAPK1HTR1A | |
| SCHEMBL10163611 | 0.72 | BCL2A1 (0.63) | IGF1RMAPTSMN1; SMN2LMNAALOX12 | |
| SCHEMBL12781841 | 0.70 | IGF1R (0.62) | IGF1RMAPTSMN1; SMN2LMNAALOX12 | |
| SCHEMBL4487672 | 0.70 | CCR1 (0.61) | MAPTSMN1; SMN2LMNAALOX12L3MBTL1 | |
| SCHEMBL4487677 | 0.70 | CCR1 (0.61) | MAPTSMN1; SMN2LMNAALOX12L3MBTL1 | |
| SCHEMBL2922701 | 0.69 | SIGMAR1 (0.62) | MAPTSMN1; SMN2LMNAALOX12L3MBTL1 | |
| SCHEMBL5185937 | 0.69 | MAPT (0.60) | IGF1RMAPTSMN1; SMN2LMNAALOX12 | |
| Hydrochloric Acid SCHEMBL5049333 | 0.69 | CCR1 (0.38) | SMN1; SMN2L3MBTL1DRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973880-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087585-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |