SCHEMBL5045841

SCHEMBL5045841

O=c1c2ccccc2oc2c([SH2+])cccc12.c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 7/20 0.53
KDM4E B2RXH2 4/20 0.49
ALDH1A1 P00352 2/20 0.49
LMNA P02545 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
CYP3A4 P08684 2/20 0.49
GLA P06280 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
PGAM1 P18669 1/20 0.49
CASP1 P29466 1/20 0.49
CASP7 P55210 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HSD17B10 Q99714 1/20 0.49
PTGS2 P35354 1/20 0.47
ADORA3 P0DMS8 1/20 0.44
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
DDR2 Q16832 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5040537 0.82 MAPT (0.33) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL3521324 0.79 MAOA (0.49) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL6879032 0.76 CYP2A6 (0.44) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL16477273 0.73 MAOA (0.60) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL12608741 0.72 MAOA (0.68) MAOAKDM4EALDH1A1LMNANPC1
Xanthone SCHEMBL28434710 0.71 MAOA (0.95) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL3369401 0.71 MAOA (0.53) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL3371463 0.70 MAOA (0.51) MAOAKDM4EALDH1A1NPC1RAB9A
SCHEMBL13005222 0.69 MAOA (0.64) MAOAKDM4EALDH1A1LMNANPC1
SCHEMBL1788224 0.69 MAOA (1.00) MAOAKDM4EALDH1A1LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1481973-B1 HETEROCYCLE-BEARING ONIUM SALTS WAKO PURE CHEM IND LTD (JP) 2008-12-31 EP disclosed