SCHEMBL13005222

SCHEMBL13005222

Bc1cccc2c(=O)c3ccccc3oc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 11/20 0.64
KDM4E B2RXH2 4/20 0.61
ALDH1A1 P00352 3/20 0.61
GLA P06280 1/20 0.61
CYP3A4 P08684 1/20 0.61
MAPT P10636 1/20 0.61
HPGD P15428 1/20 0.61
PGAM1 P18669 1/20 0.61
CASP1 P29466 1/20 0.61
CASP7 P55210 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
HSD17B10 Q99714 1/20 0.61
NPC1 O15118 2/20 0.58
LMNA P02545 1/20 0.58
RAB9A P51151 1/20 0.58
PTGS2 P35354 1/20 0.56
KDM5A P29375 1/20 0.49
TTR P02766 2/20 0.48
EGFR P00533 1/20 0.46
CYP19A1 P11511 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470697 0.84 ALOX5 (0.46) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL8711628 0.81 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL12608741 0.81 MAOA (0.68) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL24663168 0.79 ALOX5 (0.42) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL3267918 0.78 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL5782106 0.78 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL29547534 0.78 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL3383138 0.78 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL31193433 0.78 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL1788224 0.78 MAOA (1.00) MAOAKDM4EALDH1A1GLACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1896467-B1 TRICYCLIC OPIOID MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-01 EP disclosed