Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | STAT6 | P42226 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21827129 | 0.88 | CYP1A2 (0.69) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL5837665 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL18026712 | 0.84 | CYP1A2 (0.67) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL266476 | 0.82 | CYP1A2 (0.80) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1129415 | 0.81 | CYP1A2 (0.67) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1130354 | 0.81 | CYP1A2 (0.67) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL6141647 | 0.80 | CYP1A2 (0.83) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1129918 | 0.80 | CYP1A2 (0.65) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1129828 | 0.80 | CYP1A2 (0.65) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL422527 | 0.79 | CYP1A2 (0.75) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173688-B2 | Thiazole compounds, and compositions and methods using same | NEXMED HOLDINGS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20090311343-A1 | Thiazole Compounds, and Compositions and Methods Using Same | NEXMED HOLDINGS, INC. | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311343-A1 | Thiazole Compounds, and Compositions and Methods Using Same | RCC2, PKD1, REN | CYP1A2 2196/4885CYP2D6 1102/4885CYP2C19 1553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.