SCHEMBL266476

SCHEMBL266476

CCCSc1nc2ccccc2s1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.80
CYP2D6 P10635 3/20 0.80
CYP2C19 P33261 3/20 0.71
CYP3A4 P08684 2/20 0.71
CYP2C9 P11712 1/20 0.71
STAT6 P42226 1/20 0.71
HTR1A P08908 1/20 0.69
HTR2A P28223 1/20 0.69
HTR7 P34969 1/20 0.69
MAPK1 P28482 2/20 0.69
HIF1A Q16665 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
ALDH1A1 P00352 6/20 0.68
HSD17B10 Q99714 3/20 0.68
HPGD P15428 3/20 0.67
KMT2A Q03164 2/20 0.67
MEN1 O00255 1/20 0.67
SMN1; SMN2 Q16637 5/20 0.64
KDM4E B2RXH2 2/20 0.64
GFER P55789 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL422527 0.90 CYP1A2 (0.75) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL30422981 0.90 CYP1A2 (0.75) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL5837665 0.89 CYP1A2 (1.00) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL11339285 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL11299646 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL2208304 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL30423175 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL19614388 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL15501213 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL11590344 0.87 CYP1A2 (0.71) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1303311-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF Neurochem, Inc. (CA) 2003-04-23 EP claimed
WO-2002007781-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF NEUROCHEM INC. (CA) 2002-01-31 WO claimed
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD (CN) 2024-01-18 US disclosed
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD (CN) 2024-01-18 US disclosed
CN-116926578-A Method for synthesizing heteroaryl thiophenol 新疆大学 2023-10-24 CN disclosed
WO-2023146973-A1 SYNTHESIS OF A KIF18A INHIBITOR AMGEN INC. (US) 2023-08-03 WO disclosed
US-20210228550-A1 Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS 2021-07-29 US disclosed
US-10945996-B2 Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) 2021-03-16 US disclosed
US-20190209531-A1 Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS 2019-07-11 US disclosed
US-10172905-B1 Treatment of protein degradation disorders PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2019-01-08 US disclosed
US-20180185363-A1 PHTHALAZINONE DERIVATIVES KUDOS PHARMACEUTICALS LIMITED (GB) 2018-07-05 US disclosed
US-8173688-B2 Thiazole compounds, and compositions and methods using same NEXMED HOLDINGS, INC. (US) 2012-05-08 US disclosed
US-8133882-B2 Quinolone derivative or pharmaceutically acceptable salt thereof ASTELLAS PHARMA INC (JP) 2012-03-13 US disclosed
US-8133882-B2 Quinolone derivative or pharmaceutically acceptable salt thereof ASTELLAS PHARMA INC (JP) 2012-03-13 US disclosed
US-20120010204-A1 Phthalazinone Derivatives MAYBRIDGE LIMITED 2012-01-12 US disclosed
US-20090311343-A1 Thiazole Compounds, and Compositions and Methods Using Same NEXMED HOLDINGS, INC. 2009-12-17 US disclosed
US-20090197834-A1 QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ASTELLAS PHARMA INC. (JP) 2009-08-06 US disclosed
US-20090197834-A1 QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ASTELLAS PHARMA INC. (JP) 2009-08-06 US disclosed
EP-1995240-A1 QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Astellas Pharma Inc. (JP) 2008-11-26 EP disclosed
US-4245033-A AN ORGANIC SILVER SALT, A HALIDE AND A SULFUR COMPOUND EXPOSED TO FORM A SILVER IMAGE OF HIGH CONTRAST AND STABILITY CANON KABUSHIKI KAISHA (JP) 1981-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10945996-B2 Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis CASP3, SI, PYCARD CYP1A2 3963/4885CYP2D6 4825/4885CYP2C19 2607/4885
US-10172905-B1 Treatment of protein degradation disorders HDAC6, HDAC5, AADAC CYP1A2 4554/4885CYP2D6 4350/4885CYP2C19 4726/4885
US-20120010204-A1 Phthalazinone Derivatives NR0B1, NR0B2, NR2E1 CYP1A2 542/4885CYP2D6 1407/4885CYP2C19 912/4885
US-20240016775-A1 ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR PARP3, PARP1, PARP4 CYP1A2 4381/4885CYP2D6 3250/4885CYP2C19 2378/4885
US-20190209531-A1 Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis CASP3, SI, PYCARD CYP1A2 3963/4885CYP2D6 4825/4885CYP2C19 2607/4885
US-20210228550-A1 Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis CASP3, SI, PYCARD CYP1A2 3963/4885CYP2D6 4825/4885CYP2C19 2607/4885
US-20090197834-A1 QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF P2RY12, P2RY11, P2RY10 CYP1A2 2147/4885CYP2D6 1529/4885CYP2C19 281/4885
US-20180185363-A1 PHTHALAZINONE DERIVATIVES NR0B1, NR0B2, NR2E1 CYP1A2 542/4885CYP2D6 1407/4885CYP2C19 912/4885
US-20090311343-A1 Thiazole Compounds, and Compositions and Methods Using Same RCC2, PKD1, REN CYP1A2 2196/4885CYP2D6 1102/4885CYP2C19 1553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.