Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.52 |
| ▸ | PDE2A | O00408 | 6/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461106 | 0.79 | HDAC3 (0.64) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6461129 | 0.78 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6470934 | 0.78 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6454685 | 0.78 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL7732006 | 0.77 | ACACB (0.61) | ACACB | |
| SCHEMBL6533981 | 0.77 | HDAC3 (0.61) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6456071 | 0.77 | HDAC3 (0.61) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6455995 | 0.76 | NR1H4 (0.66) | HDAC3HDAC4HDAC1HDAC6PDE2A | |
| SCHEMBL6454613 | 0.76 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6PDE2A | |
| SCHEMBL6455555 | 0.72 | ACACB (0.57) | HDAC3HDAC4HDAC1HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396944-B2 | Thiophene derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | claimed |
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | claimed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |